Ser326Cys polymorphism of 8-oxoguanine DNA glycosylase 1 (OGG1) in men with teratozoospermia

Background:The increase in seminal reactive oxygen species (ROS) has been linked to DNA oxidation and abnormalities in sperm morphology.The enzyme 8-oxoguanine DNA glycosylase 1 (OGG1) repairs DNA oxidation.However, the presence of the polymorphism in OGG1 that involves a change of cytokine (C) to guanine (G) resulting in the substitution of a cystine for serine at codon 326 (Ser326Cys) has shown a decrease in the repair of oxidized DNA.Studies of the Ser326Cys polymorphism in Spanish and Asian men with infertility demonstrated that the G(Cys) allele increases ROS, impacting infertility and teratozoospermia.Objective: To know the prevalence of the Ser326Cys polymorphism of OGG1 in patients with teratozoospermia.Method: Sperm parameters and the Ser326Cys polymorphism of OGG1 were analyzed from 81 semen samples.Results: The genotypes detected were Ser326Ser(CC) 43%, Ser326Cys(CG) 41%, and yis326Cys(GG) 16%.The frequency of the G allele (Cys) was 0.4, a value higher than the frequency reported in the databases available for American populations (0.21-0.29), the sperm parameters were not related to the Ser326Cys polymorphism.Conclusion: The G (Cys) allele is a factor that contributes to infertility.