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June 4, 2024Open Access

Supplementary Figure S5 from Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy

Jialei Weng Zheng Wang Zhiqiu Hu Wenxin Xu Jialei Sun Fu Wang Qiang Zhou Shaoqing Liu Min Xu Minghao Xu Dongmei Gao Ying-Hao Shen Yong Yi Yi Shi Qiongzhu Dong Chenhao Zhou Ning Ren

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Key Points

Clophosome treatment reduces tumor volume and tumor weight in orthotopic hepatocellular carcinoma models, establishing the therapeutic impact on tumor burden.
Assessment of Hepa1-6 liver tumors across five mice per group reveals significant inhibition of growth based on one-way anova with post hoc LSD comparisons.
Targeting immunosuppressive macrophages via CCL2 signaling may improve immunotherapy efficacy; however, results are restricted to an orthotopic mouse model.

Implication

Animal study reveals tumor reduction via macrophage depletion in hepatocellular carcinoma models, suggesting enhanced response to immunotherapy.

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Cite This Study

Weng et al. (2024) studied this question.

synapsesocial.com/papers/68e664bab6db6435875f135f https://doi.org/10.1158/0008-5472.25964594

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S5 from Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy2024
2Supplementary Figure S7 from Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy2024
3Supplementary Figure S7 from Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy2024
4Supplementary Figure S11 from Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy2024
5Supplementary Figure S11 from Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy2024

Supplementary Figure S2 from Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy2024
Supplementary Figure S2 from Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy2024
Supplementary Figure S1 from Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy2024