Supplementary Figure S4 from Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6

Fig. S4. huAR9.6 effects on PDAC cells and PDXs. Representative wound healing assay of vehicle (PBS), isotype control huIgG (40 µg/mL) and huAR9.6 (40 µg/mL) treated (A) T3M4 and (B) Capan-1 cells. (C) Schematic of patient-derived xenograft (PDX) derived cells obtained from primary human PDAC and liver metastasis. (D) Flow cytometric assessment of apoptosis using the Annexin-V/PI assay in T3M4 and Capan-1 cells treated with vehicle (PBS), isotype control huIgG (40 µg/mL) and huAR9.6 (40 µg/mL). Mean ± SD (n=3), p