Supplementary Figure S10 from Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6

Fig. S10. Conservation of AR9.6 epitope in homologous SEA domains. The epitope deduced from the X-ray structure of AR9.6 in complex with SEA5 (yellow ribbon diagram) occurs in 3 regions of the protein (shown in orange). (A) Alignment of SEA5 with homologous MUC16 SEA domains reveals that the epitope is well conserved among SEA domains 3-13, (B) less well conserved in SEA domains 1-2 (C), and the least conserved in SEA domains 13,14,16. (D) No significant epitope conservation occurs in SEA domain 15.