Figure 2 from Cigarette Smoking and E-cigarette Use Induce Shared DNA Methylation Changes Linked to Carcinogenesis

Combined methylation scores of CpGs in the four sets and annotation. A, Association of mean methylation β values in each of the sets described in Fig. 1C with immune cell proportion in buccal and cervical samples and lymphoid proportion in blood samples in the discovery set. B, Venn Diagram of genes associated with CpGs in each of the four smoking-associated sets of CpG indicates little overlap between involved genes. C–F, Gene ontology (C–E) and Reactome pathway enrichment (F) for the four sets of smoking-associated CpGs reveals different pathways.