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June 3, 2024MoleculesOpen Access

Design, Synthesis, and Antitumor Activity of Isoliquiritigenin Amino Acid Ester Derivatives

Chi Liu Xinyue Liu Qing Ma Su Fengyan Enbo Cai

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Abstract

Isoliquiritigenin (ISL) is a chalcone that has shown great potential in the treatment of cancer. However, its relatively weak activity and low water solubility limit its clinical application. In this study, we designed and synthesized 21 amino acid ester derivatives of ISL and characterized the compounds using

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Cite This Study

Liu et al. (2024) studied this question.

synapsesocial.com/papers/68e66715b6db6435875f2c5f https://doi.org/10.3390/molecules29112641

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms2025 · 2 citations
2Optimization of response surface methodology for the extraction of isoliquiritigenin from Aspergillus niger solid-state fermentation of licorice and its antitumor effects2025
3Isoliquiritigenin Suppresses Breast Tumor Development by Enhancing Host Antitumor Immunity2024 · 9 citations
4Unveiling the Mechanism of Action of Isoliquiritigenin in Suppressing Co- Expression of HER2 and HER3 in Breast Cancer: Implications for Clinical Application2024 · 1 citations
5Isoliquiritigenin from Licorice Attenuates Metastatic Development of Pancreatic Cancer by Regulation of Selective Autophagy-Mediated Ferroptosis and the Tumor MicroenvironmentOriginal Research · 2026

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An Integrated Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and Experimental Validation Study to Investigate the Potential Mechanism of Isoliquiritigenin in the Treatment of Ischemic Stroke2025
P01.01 Isoliquiritigenin attenuated metastatic development of pancreatic cancer by regulation of the tumor microenvironment and reactivation from chemoresistance2024

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