Figure 3 from Assessing the Value of Incorporating a Polygenic Risk Score with Nongenetic Factors for Predicting Breast Cancer Diagnosis in the UK Biobank

Decision curve analysis for Tyrer–Cuzick and Gail 10-year risk scores with and without PRSBC in test data (N = 25,359). Plots show net benefit calculated in full available follow-up time. The gray line indicates net benefit if all women were screened, and the black line indicates net benefit if no women were screened.