A Long-Term Toxicology Study of the Nutraceutical 2036 Specialty-Gaoqing Recipe Administered to Rats

Abstract 2036 Specialty-Gaoqing recipe (2036S-GQR) is a nutraceutical that content docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), grape seed proanthocyanin extract, and bilberry anthocyanins extract. All these ingredients have been proven having various health benefit and 2036S-GQR has been widely and long use in China. However, the toxicity of long-term administration has not yet been reported. The present study explores the long-term toxicity of 2036S-GQR in Wistar rats following the OECD 407 and 408 guidelines. Three dose group was orally administered 2036S-GQR 0.6, 1.2, 2.0 g/kg body weight six day per week for 26 weeks respectively, whereas control group provided distilled water. The investigation of food intake, body weight, hematological, biochemical, and histopathological data was performed in 12, 26 weeks and at the end of recovery period (30 weeks) which was used to assess the toxic effects. The result displays no evident sign of toxicity, no clinically significant change emerges in all measuring data and observation in all dose group, demonstrating 2036S-GQR is harmless to the body under the arranged dose.