Use of ultrasensitive RNA in situ hybridization for kappa and lambda light chains assists in the differential diagnosis of B‐cell non‐Hodgkin and Hodgkin lymphomas in cytopathology practice

Ultrasensitive RNA in situ hybridization for light chain is a relatively new diagnostic tool that aids in the diagnosis of B‐cell lymphomas. The approach has been shown to be as sensitive as flow cytometry in assessing light chain restriction.