In vitro study demonstrates pH-responsive drug release and cytocompatibility in cultured cell lines, highlighting their promise for bioactive wound healing applications.
Key Points
Blended biopolymer hydrogels successfully mimic the natural extracellular matrix, exhibiting distinct pH-responsive swelling and controlled release of neomycin.
Swelling reached a maximum of 2139.73 % in aqueous media for carboxymethyl cellulose blends, exceeding the 1639.17 % peak recorded in saline buffer.
Assessment using the Franz diffusion method at 37 °C and in vitro cell cultures characterized neomycin release alongside biomaterial cytocompatibility.
Supports potential bioactive wound dressing utility by promoting angiogenesis; however, findings rely on in vitro cell lines, requiring in vivo validation.