Combined uterine and colorectal screening: A call for action.

5615 Background: Colon cancer is currently one of the top three malignancies in the US with routine screening guidelines in place. With the current rise in uterine cancer incidence and mortality, there is currently no screening for uterine cancer. We propose to evaluate the demographics and trends in uterine and colorectal cancer incidences among women in the United States. Methods: Uterine and colorectal cancer incidence data among U.S. women were collected from the United States Cancer Statistics (USCS) database from 2001-2019. Annual estimated uterine and colon cancer incidence data among women was obtained from the American Cancer Society (ACS) from 2015-2024. SEER*Stat 8.3.9.2 and Joinpoint regression program 4.9.0.0 were used to calculate cancer incidences and trends per 100,000. Average annual percentage change (AAPC) was used to describe trends. Age-adjusted incidences were adjusted by the U.S. 2000 standard population. SAS Enterprise Guide v 7.1 was employed to analyze estimated cancer incidences. Results: From 2001-2019, 904,032 incident uterine cases were identified from USCS. Regarding race, 76.5% identified as non-Hispanic White, 10.5% as non-Hispanic Black, 8.38% as Hispanic, and 3.42% as non-Hispanic Asian/Pacific Islander. Of the 1,337,470 incident colorectal cancer cases obtained from USCS, 76.4% identified as White, 12.1% as Black, 7.10% as Hispanic, and 3.23% as Asian. Using ACS data from 2015-2024, the estimated number of annual incident uterine cancer cases increased from 54,870 to 67,880 while colorectal cancer incidence changed from 63,610 to 71,270 cases over the past 10 years (p<0.0001). Using a projection model, we predict that the incidence of uterine cancer will surpass colon cancer by 2025 at 40.17 and 37.07/100,000 respectively (Table). Given that Black women have a high rate of increasing uterine cancer incidence (AAPC 2.88%; p<0.0001), we predict that uterine cancer incidence among Black populations will surpass their rate of colon cancer by 2025 (42.97 vs 35.10/100,000). Conclusions: These findings suggest that uterine cancer incidence is increasing at a concerning rate and will likely surpass colon cancer by 2025. The impact of health disparities on Black women calls for research on the need for screening and novel therapies. [Table: see text]