Ab0205 Hyperuricemia’s Association With Left Atrium Diameter and Relative Wall Thickness in Inflammatory Rheumatic Diseases

Background: An increase in left atrial diameter (LAD) and a greater relative wall thickness (RWT) of the left ventricle (LV) has been associated with a greater risk of suffering cardiovascular disease (CVD). It has been shown that hyperuricemia can lead to an increase in LAD and greater RWT in healthy adults, but its effect in patients with inflammatory rheumatic disease has not been established. Objectives: Compare the LAD and RWT in patients diagnosed with inflammatory rheumatic disease with and without hyperuricemia. Methods: A cross-sectional study was carried out, including patients aged 40 to 75 years who met the classification criteria for ACR/EULAR 2010 for Rheumatoid Arthritis (RA) and the Classification Criteria for Psoriatic Arthritis (CASPAR) 2006 for Psoriatic Arthritis. Patients with a history of cardiovascular events, overlap syndromes, or pregnancy were excluded. Biochemical profiles were performed to calculate serum uric acid (SUA) levels. Hyperuricemia was considered as a SUA level > 6.8 mg/dL. Transthoracic echocardiograms were performed by a board-certified cardiologist, blinded to clinical information. The distribution was evaluated using the Kolmogorov-Smirnov test, comparisons were made with the Chi-square test, Fisher's exact test, Student's T-test, or u-Mann Whitney test, depending on the case. A p-value < 0.05 was taken as statistically significant. Results: Our study included 32 patients, mainly men (62.5%). The average age was 53.75 (±7.76). The most frequent diagnosis was PsA with a frequency of 65.6%. It was found that patients with hyperuricemia showed larger LAD than patients without hyperuricemia [4.05 vs. 3.45, p=0.003]. Patients with hyperuricemia showed higher RWT compared to patients without hyperuricemia [0.47 vs. 0.39, p=0.000]. Patients with hyperuricemia also had higher prevalences of hypertension [9 (64.3) vs. 8 (44.4); p=0.021] with no significant differences in prevalence for other comorbidities. (Table 1) Conclusion: In our cohort, LAD and left ventricular RWT were elevated in patients with inflammatory rheumatic disease and hyperuricemia. Complete cardiovascular evaluations are recommended in patients with autoimmune disease and hyperuricemia. REFERENCES: NIL. Acknowledgements: NIL. Disclosure of Interests: None declared.