Ab0149 Assessment of the Central Sensitization by the Central Sensitization Inventory in Patients With Rheumatoid Arthritis

Background: Pain is one of the most prominent symptoms of rheumatoid arthritis (RA), which significantly affects the functional capabilities of such patients and significantly worsens their quality of life 1. Recent evidence has demonstrated that Central Sensitization (CS) may be a new mechanism for the pain experienced by these patients 2. The Central Sensitization Inventory (CSI) is a new self-report screening instrument to identify patients whose symptoms may be related to the phenomenon of CS 3. Objectives: Our aim was to determine the prevalence of central sensitization in RA patients using CSI. Methods: The study involved patients with RA according to ACR/EULAR (2010) criteria. We administered to all the subjects in the study the CSI, a questionnaire that has been used for the diagnosis of central sensitivity syndromes (CSS). DAS28-ESR, CDAI, SDAI, pain VAS, and HAQ-DI were compared in the "CS group (CSI ≧ 40)" and the "non-CS group (CSI Results: Overall, 176 patients with RA (median age, 52.2 ± 1.5 years; 78% female) and 36 controls (median age, 44,5 ± 2 years; 72% female) were included, of which 36% and 11%, respectively, had a CS (CSI score of 40 or higher), p Conclusion: Central sensitization is common in RA patients. In the present study, admission CSI scores were highly associated with disease-specific values in RA patients. The CSI may have important clinical utility as a screening and treatment outcome measure for patients with RA. REFERENCES: 1 Martinec, R., Pinjatela, R., & Balen, D. (2019). QUALITY OF LIFE IN PATIENTS WITH RHEUMATOID ARTHRITIS - A PRELIMINARY STUDY. Acta clinica Croatica, 58(1), 157–166. https://doi.org/10.20471/acc.2019.58.01.20 2 Nijs, Jo, George, Steven Z, Clauw, Daniel J, Fernández-de-las-Peñas, César, Kosek, Eva, Ickmans, Kelly, Fernández-Carnero, Josué, Polli, Andrea, Kapreli, Eleni, Huysmans, Eva, Cuesta-Vargas, Antonio I, Mani, Ramakrishnan, Lundberg, Mari, Leysen, Laurence, Rice, David, Sterling, Michele, and Curatolo, Michele (2021). Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine. The Lancet Rheumatology 3 (5) e383-e392. https://doi.org/10.1016/S2665-9913(21)00032-1. 3 Neblett, R. (2018). The central sensitization inventory: A user's manual. Journal of Applied Biobehavioral Research, 23(2), e12123. doi:10.1111/jabr.12123. Acknowledgements: NIL. Disclosure of Interests: None declared.