Ab1304 Patients With Takayasu Arteritis Experience Worse Quality of Life, Physical Function, Work Productivity, Anxiety, Depression, and Fatigue Than Healthy Individuals Which Persist Over Time

Background: Since the literature on patient-reported outcome measures (PROMs) in Takayasu arteritis (TAK) is scarce 1, we comprehensively assessed PROMs in a cohort of TAK longitudinally and compared them with healthy individuals. Objectives: Comparison of PROMs in patients with Takayasu arteritis and healthy controls. Comparison of PROMs in inactive and active Takayasu arteritis. To evaluate changes in PROMs on longitudinal follow-up. Methods: Consecutive adult patients with TAK were prospectively evaluated for quality of life (QOL, using EQ-5D-3L questionnaire), physical function using health assessment questionnaire (HAQ), physical activity (using International Physical Activity Questionnaire – Short Form (IPAQ-SF)], work productivity using Work Productivity and Activity Impairment- General Health v2(WPAI), anxiety using generalized anxiety disorder assessment 7 questionnaire (GAD-7), depression using patient health questionnaire 9 (PHQ-9), fatigue using 13-item Functional Assessment of Chronic Illness Therapy Fatigue Scale (FACIT, lower FACIT scores indicate greater fatigue) and Multidimensional Fatigue Inventory (MFI), and fibromyalgia using 2010 diagnostic criteria from the American College of Rheumatology (ACR), including the polysymptomatic distress scale (PSD) score. PROMs were compared between TAK and healthy controls, and between TAK with active or inactive disease as per physician global assessment. PROMs were reassessed in TAK after 6-18 months to assess the stability of observations. Medians with interquartile range (Q1-Q3) were used to represent the data (unpaired data compared using Mann-Whitney U test, paired data using Wilcoxon matched-pairs signed rank test). Categorical data were compared using Chi-square test. pResults: Eighty-four patients with TAK 61 females, median age 34(25-44) years, disease duration 66.5 (37.7-125.8) months were compared with 61 healthy controls 45 females, age 30 (28-40) years. TAK had worse QOL on EQ-5D visual analog scale and higher scores in domains of mobility, self-care, usual activities, pain/discomfort, and anxiety/depression of the EQ-5D-3L than healthy controls (Figure 1A). Patients with TAK had worse physical function (HAQ), greater activity impairment due to health (using the WPAI), higher anxiety (GAD-7) and depression (PHQ-9) scores, worse fatigue scores (MFI, FACIT) and PSD scores than healthy controls (Figure 2A). Similar proportions of TAK (6/84) or controls (1/61) fulfilled the 2010 ACR diagnostic criteria for fibromyalgia (p=0.239). Active TAK (n=13) had worse scores on the mobility domain of EQ-5D-3L (Figure 1B), higher activity impairment due to health (using WPAI) and worse fatigue (MFI, FACIT) and PSD scores than inactive TAK (n-71) (Figure 2B). Repeat measurements of PROMs in 75 patients with TAK after a median 6.5 (6-9) months revealed no significant differences (Figures 1C and 2C). Conclusion: Patients with TAK have worse patient-reported outcome measures than healthy controls which remain similar on longitudinal assessment. Active TAK have worse fatigue and work impairment than inactive TAK. REFERENCES: 1 Misra DP, et al. Rheumatol Ther 2021;8(3):1073-93. Acknowledgements: NIL. Disclosure of Interests: None declared.