Ab1304 Patients With Takayasu Arteritis Experience Worse Quality of Life, Physical Function, Work Productivity, Anxiety, Depression, and Fatigue Than Healthy Individuals Which Persist Over Time

Background: Since the literature on patient-reported outcome measures (PROMs) in Takayasu arteritis (TAK) is scarce [1], we comprehensively assessed PROMs in a cohort of TAK longitudinally and compared them with healthy individuals. Objectives: Comparison of PROMs in patients with Takayasu arteritis and healthy controls. Comparison of PROMs in inactive and active Takayasu arteritis. To evaluate changes in PROMs on longitudinal follow-up. Methods: Consecutive adult patients with TAK were prospectively evaluated for quality of life (QOL, using EQ-5D-3L questionnaire), physical function [using health assessment questionnaire (HAQ)], physical activity (using International Physical Activity Questionnaire – Short Form (IPAQ-SF)], work productivity [using Work Productivity and Activity Impairment- General Health v2(WPAI)], anxiety [using generalized anxiety disorder assessment 7 questionnaire (GAD-7)], depression [using patient health questionnaire 9 (PHQ-9)], fatigue [using 13-item Functional Assessment of Chronic Illness Therapy Fatigue Scale (FACIT, lower FACIT scores indicate greater fatigue) and Multidimensional Fatigue Inventory (MFI)], and fibromyalgia [using 2010 diagnostic criteria from the American College of Rheumatology (ACR), including the polysymptomatic distress scale (PSD) score]. PROMs were compared between TAK and healthy controls, and between TAK with active or inactive disease as per physician global assessment. PROMs were reassessed in TAK after 6-18 months to assess the stability of observations. Medians with interquartile range (Q1-Q3) were used to represent the data (unpaired data compared using Mann-Whitney U test, paired data using Wilcoxon matched-pairs signed rank test). Categorical data were compared using Chi-square test. p<0.05 were considered significant. Results: Eighty-four patients with TAK [61 females, median age 34(25-44) years, disease duration 66.5 (37.7-125.8) months] were compared with 61 healthy controls [45 females, age 30 (28-40) years]. TAK had worse QOL on EQ-5D visual analog scale and higher scores in domains of mobility, self-care, usual activities, pain/discomfort, and anxiety/depression of the EQ-5D-3L than healthy controls (Figure 1A). Patients with TAK had worse physical function (HAQ), greater activity impairment due to health (using the WPAI), higher anxiety (GAD-7) and depression (PHQ-9) scores, worse fatigue scores (MFI, FACIT) and PSD scores than healthy controls (Figure 2A). Similar proportions of TAK (6/84) or controls (1/61) fulfilled the 2010 ACR diagnostic criteria for fibromyalgia (p=0.239). Active TAK (n=13) had worse scores on the mobility domain of EQ-5D-3L (Figure 1B), higher activity impairment due to health (using WPAI) and worse fatigue (MFI, FACIT) and PSD scores than inactive TAK (n-71) (Figure 2B). Repeat measurements of PROMs in 75 patients with TAK after a median 6.5 (6-9) months revealed no significant differences (Figures 1C and 2C). Conclusion: Patients with TAK have worse patient-reported outcome measures than healthy controls which remain similar on longitudinal assessment. Active TAK have worse fatigue and work impairment than inactive TAK. REFERENCES: [1] Misra DP, et al. Rheumatol Ther 2021;8(3):1073-93. Acknowledgements: NIL. Disclosure of Interests: None declared.