Ab0054 Predictive Role of Central Sensitization in Kinesiophobia and Exercise Capacity in Behcet Disease

Background: Behcet's disease (BD) may experience heightened pain sensitivity, potentially related to central sensitization (CS), especially if the nervous system is involved in the disease process. Objectives: This study aims to determine the frequency of CS in BD patients and to evaluate the relation of CS with fear of falling, exercise capasity, disease activity, and quality of life. To evaluate the correlations of these parameters with the CS score. Methods: Forty-eight patients with BD were included in the study between September 2023 and December 2023. Tampa Kinesiophobia Scale(TKS), six-minute walk test (6MWT), and the central sensitization inventory short form was administered to all participants. The activity of BD was determined by the Behçet's disease current activity form (BDCAF). Results: CS was detected in 59.6% of patients with BD. Of the 22 of 48 patients (45.8%) were male, the mean patient age was 41.6±11.2, and the median disease duration was 8 (10) years. In their current treatments, 35 of them (72.9%) were using colchicine, and 20 of them (41.7%) were using azatiopurine. In patients with CS, fear of exercise was higher, quality of life was poor, and disease activity was significantly higher. These patients had higher 6MWT pre- and post-test muscle fatigue scores and shorter walking distances (Table 1). There were high correlations between the CS scores and the TKS, 6MWT, and BDCAF scores in patients with BD (Rho = 0.526; p <.001, Rho = 0.474; p.001, and Rho = 0.560; p<.001, respectively) Table 2. Conclusion: CS is associated with kinesiophobia, decreased exercise capacity, and higher disease activity in Behcet's patients. REFERENCES: NIL. Acknowledgements: NIL. Disclosure of Interests: None declared.