Experimental study of synthesis of N-2-Hydroxypropyltrimethylammonium chloride chitosan and carboxymethyl chitosan nanoparticles by ultrasonic microreactor

To overcome the technical limitations of current batch reactors for synthesizing N-2-HACC/CMCS NPs, an ultrasonic microreactor was designed and fabricated to continuously prepare N-2-HACC/CMCS NPs, which were characterized by SEM, laser particle sizing instrument, and FTIR. The findings indicate that the granular size of the NPs can be precisely regulated by changing the conditions of reaction temperature, ultrasonic power, reactant flux ratio, and reactant concentration. Compared with the batch reactor, ultrasonic microreactors can continuously prepare NPs with smaller and more uniform particle sizes.