Predictive Pathologic Features of Nodal Metastasis and Tumor Recurrence in HPV-Associated Endocervical Adenocarcinoma

Endocervical Adenocarcinoma (EAC) is the second most prevalent malignancy of the uterine cervix, with a significant portion linked to high-risk HPV infection 1. The incidence of EAC has risen notably, now accounting for up to 25% of new cervical cancer diagnoses at 1.44/100,000 women in the United States 2. Overall survival is mainly related to the FIGO (International Federation of Gynecology and Obstetrics) stage with decreased survival in advanced staging.