DYNA: Disease-Specific Language Model for Variant Pathogenicity

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Disease-Specific Prediction of Missense Variant Pathogenicity with DNA Language Models and Graph Neural Networks2025
2. 2Disease-specific variant pathogenicity prediction using multimodal biomedical language models2025
3. 3Expanding the utility of variant effect predictions with phenotype-specific models2025
4. 4Discordance between a deep learning model and clinical-grade variant pathogenicity classification in a rare disease cohort2024 · 1 citations
5. 5Disease- and gene-specific deep learning for pathogenicity prediction of rare missense variants in cancer predisposition genes2026