Insufficient diffusion of tedizolid in cerebrospinal fluid: about a case report and mini-review of literature

Abstract Background: Tedizolid, a recent oxazolidinone developed for skin and soft tissues infection with bacteriostatic activity, is believed to have identical pharmacokinetic parameters to linezolid with less myelosuppression and neurotoxicity. However, its neuro-meningeal diffusion seems different than linezolid. This case report and this review aim to investigate the diffusion of this molecule. Case presentation: We report a clinical case of meningitis secondary to skull base osteomyelitis and we present a rapid review of literature. Liquid chromatography coupled with mass tandem spectrometry was used to measure tedizolid concentration. The trough concentration in CSF was under the limit of quantification while serum concentration was appropriate. A short review of the literature seems to confirm that meningeal diffusion is weaker than linezolid. Conclusion: It is therefore important to be cautious when prescribing tedizolid in neuro-meningeal infections, especially if targeted pathogens have high MICs.