Abstract Objective To determine the effectiveness of phase-change-material mattress (PCM) during transportation of newborns with hypoxic ischemic encephalopathy (HIE). Study design: Randomized controlled trial of newborns with HIE from June 2016 to December 2019. Patients were randomized to transport with PCM or without PCM (control) when transferred to a cooling center in northern Vietnam. Result 52 patients in PCM-group and 61 in control group. Median rectal temperature upon arrival was 34.5°C (IQR 33.5–34.8) in PCM-group and 35.1°C (IQR 34.5–35.9) in control group (p = 0.023). Median time from birth to reach target temperature was 5.0 ± 1.4 hours and 5.5 ± 1.2 hours in the respective groups (p = 0.065). 80.8% of those transported with PCM versus 62.3% of infants transported without (p = 0.049) had reached target temperature within the 6-hour timeframe. There was no record of overcooling (< 32°C) in any of the groups. The mortality rate was 33% and 34% respectively (p > 0.05). Conclusion Phase-change-material can be used as a safe and effective cooling method during transportation of newborns with HIE in low-resource settings.
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Tran et al. (2024) studied this question.
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