Review summarizes genetic models of congenital heart disease and underlying biochemical pathways, highlighting key experimental advantages and translational challenges.
Congenital heart disease (CHD) encompasses a diverse range of structural and functional anomalies that affect the heart and the major blood vessels. Epidemiological studies have documented a global increase in CHD prevalence, which can be attributed to advancements in diagnostic technologies. Extensive research has identified a plethora of CHD-related genes, providing insights into the biochemical pathways and molecular mechanisms underlying this pathological state. In this review, we discuss the advantages and challenges of various
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Shorbaji et al. (2024) studied this question.
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