Uric Acid/ HDL Ratio as a Marker of Disease in Coronary Artery Ectasia Versus Normal Coronaries

Objective: To determine the strength of association of raised uric acid/ High-Density Lipoprotein ratio in patients with Coronary Artery Ectasia versus normal coronaries. Study Design: Analytical Cross-sectional study. Place and Duration of Study: Armed Forces Institute of Cardiology/National Institute of Heart Diseases, Rawalpindi, Dec 2022 to May 2023 Methodology: Total n=146 patients aged between 20-90 years of both gender, with chest pain who had CAE or unobstructed coronaries on coronary angiography, and normal heart structure and valvular function were included. Patients were divided into two groups: those with Coronary Artery Ectasia (Group-I) and those without Coronary Artery Ectasia (Group-II). Serum uric acid and High-Density Lipoprotein level were measured for each patient and their ratio was calculated. Qualitative variables were compared across groups using the Chi-square test/Fischer Exact test, while quantitative variables were compared using the independent samples t-test. Univariate and multivariate logistic regression analysis was used to predict the odds ratio to show association between predictors and outcome (Coronary Artery Ectasia) and p<0.05 was considered as statistically significant Results: Study sample n=146 had mean age of 52.83 ± 9.67 years, comprised of 113(77.4%) males and 33(22.6%) females. Uric acid to HDL ratio above 0.12 had an adjusted odds ratio (aOR) of 9.3 (CI 95% 3.3–26.0) for having Coronary artery ectasia (p<0.001). Males and age of 60 years or greater were also associated with an increased odds, with (aORs) of ..... Conclusion: Uric acid/HDL ratio is a useful variable in predicting odds of coronary artery ectasia in patients with chest pain.