Presynaptic nanoscale components of retrograde synaptic signaling

Benjámin Barti; Barna Dudok; Kata Kenesei; Miklós Zöldi; Vivien Miczán; Gyula Y. Balla; Diana Zala; Mariana Tasso; Claudia Sagheddu; Máté Kisfali; Blanka Tóth; Marco Ledri; E. Sylvester Vizi; Miriam Melis; L Barna; Zsolt Lenkei; Iván Soltész; István Katona

doi:10.1126/sciadv.ado0077

Key Points

Tonic cannabinoid signaling is essential for establishing target cell-dependent variability, operating independently of the two primary endocannabinoid-producing enzymes.
Physiological, anatomical, and molecular measurements at the unitary synapse demonstrate that nanoscale organization shapes presynaptic transmission and functional variability.
Target-dependent nanoscale stoichiometric ratios of type 1 cannabinoid receptors may govern retrograde synaptic signaling, though animal model validation remains essential.

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Implication

Experimental analysis reveals tonic cannabinoid signaling determines transmission variability in unitary synapses, highlighting nanoscale receptor organization.

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Barti et al. (2024) studied this question.

synapsesocial.com/papers/68e67cc7b6db643587606e0c https://doi.org/10.1126/sciadv.ado0077

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Presynaptic nanoscale components of retrograde synaptic signaling

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Presynaptic nanoscale components of retrograde synaptic signaling

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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