Immunological criteria for the risk of vascular disaster in persons living and working in the Arctic

The work presents immunological criteria for the risk of vascular accidents in people living and working in the Arctic. 356 people aged 21 to 55 years were examined, 227 women and 129 men, of which 123 people living in the Svalbard archipelago (Barentsburg village) and in the Murmansk region (Revda and Lovozero villages). The comparison group included 121 practically healthy people of the specified age range at the time of the examination and 112 people diagnosed with coronary heart disease living in the Arkhangelsk region. It has been established that hyperfunction of the cardiovascular system in residents of the Arctic is ensured by increased level reactions from endothelin-1, brain natriuretic peptide, transferrin, transferrin receptor, intercellular adhesion molecules sCD54, sCD62L,pro-inflammatory cytokine TNF-α, autoantibodies to cardiolipids, autoantibodies to phospholipids, circulatingimmune complexes containing IgM and C3D.