CRISPR-Cas13b-mediated suppression of HBV replication and protein expression

Laura C. McCoullough; Mohamed Fareh; Wenxin Hu; Vitina Sozzi; Christina Makhlouf; Yianni Droungas; Chee Leng Lee; Mina Takawy; Stewart A. Fabb; Thomas J. Payne; Colin W. Pouton; Hans Netter; Sharon R. Lewin; Damian F. J. Purcell; Jacinta A. Holmes; Joseph A. Trapani; Margaret Littlejohn; Peter Revill

doi:10.1016/j.jhep.2024.05.025

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Abstract

New antiviral approaches that target multiple aspects of the HBV replication cycle to improve rates of functional cure are urgently required. HBV RNA represents a novel therapeutic target. Here, we programmed CRISPR-Cas13b endonuclease to specifically target the HBV pregenomic RNA and viral mRNAs in a novel approach to reduce HBV replication and protein expression.

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McCoullough et al. (2024) studied this question.

synapsesocial.com/papers/68e680e5b6db6435876097ec https://doi.org/10.1016/j.jhep.2024.05.025

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CRISPR-Cas13b-mediated suppression of HBV replication and protein expression

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Abstract

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CRISPR-Cas13b-mediated suppression of HBV replication and protein expression

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Abstract

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