Influence of Smoking on the Concentration of Nitric Oxide in the Expired AIr of Patients With Copd

In recent years, the attention of researchers has been drawn to the study of the state of the vascular endothelium in various diseases.The endothelium produces vasorelaxing and vasoconstrictor substances, as well as a number of enzymes that affect their activation.In the last decade, close attention has been paid to such a vasoactive substance as NO.It is known that NO is one of the most important mediators characterizing inflammation in the respiratory system.Inaddition, it has been proven that the accumulation of NO leadstore laxation of the bronchi.The development of endothelial dysfunctionin COPD is determined by the presence of hypoxia and an increasein the content of various biological lyactive substances, as well as exposure to tobacco smoke.Since the main etiological factor in COPD is smoking, it is important to study the influence of this factor on the level of NO in exhaled air condensate.The aim of the study was to study the effect of active tobacco smoking on the level of NO in exhaled air in patients suffering from COPD.28 men were examinedwith verifieddiagnosis of COPD duringremission.During the examination, all patients were divided into 2 groups:depending on the presence of the smoking factor.All patients underwent spirometry and determination of NO levels in exhaled air.It was found that the factor of tobacco smoking in patients with COPD in remission affects the level of NO concentration in exhaled air, causing it to significantly decrease compared to the level in non-smoking patients.The degree of tobacco load (duration and intensity of smoking) does not affect the level of NO concentration in exhaled air in patients with COPD in remission.The degree of nicotine dependence affects the level of NO concentration in exhaled air in patients with COPD in the remission phase.The level of NO concentration in exhaled air in smoking and non-smoking patients with COPD in the remission phase does not depend on the severity of broncho-obstructive manifestations.