Self-Assembled Porphyrin Nanoparticles Interaction Analysis with Albumin by Dynamic Light Scattering

We herein introduce the study of self-assembled porphyrazine nanoparticles photosensitizers in aqueous solutions with and without a polyvinylpyrrolidone carrier, respectively. For the first time, distributions of hydrodynamic radii for each of the samples separately were obtained, as well as corresponding changes in distributions for multicomponent systems in the presence of human serum albumin. For reliable interpretation of the obtained distributions, a statistical processing method adapted to biological samples was used. The study identified combinations of photosensitizer nanoparticles that could either efficiently interact with human transport proteins or, conversely, maintain their stability in their presence. Thus, the research conducted via dynamic light scattering revealed the potential for fundamentally different passive delivery methods of these nanoparticles: both with and without interaction with the main transport protein of human blood.