⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

May 27, 2024Medicinal Chemistry

New Thieno[2,3-d]pyrimidines as Anticancer VEGFR-2 Inhibitors with Apoptosis Induction: Design, Synthesis, and Biological and In Silico Studies

Eman A. Sobh Mohammed A. Dahab Eslam B. Elkaeed Bshra A. Alsfouk Ibrahim M. Ibrahim Ahmed M. Metwaly Ibrahim H. Eissa

View at Publisher

Ask AI

Bookmark

Share

Abstract

Vascular endothelial growth factor receptor-2 (VEGFR-2) is a critical protein involved in tumor progression, making it an attractive target for cancer therapy.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Sobh et al. (2024) studied this question.

synapsesocial.com/papers/68e68387b6db64358760cada https://doi.org/10.2174/0115734064285433240513092047

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Discovery of new thiadiazole-based VEGFR-2 inhibitors: design, synthesis, cytotoxicity, and apoptosis induction2025 · 7 citations
2Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting AgentsIn Vitro Study · 2016 · 180 citations
3Development and assessment of novel pyrazole–thiadiazol hybrid derivatives as VEGFR-2 inhibitors: design, synthesis, anticancer activity evaluation, molecular docking, and molecular dynamics simulation2024 · 2 citations
4Synthesis, cytotoxicity assessment and molecular docking of novel thienyl-pyrazoles as VEGFR2 Inhibitors.2024 · 4 citations
5Scaffold-Hopping Design and Synthesis of Thieno[3,2-d]pyrimidines: Anticancer Activity, Apoptosis Induction, and In Silico Inhibition of CDKs2025 · 5 citations

Thieno[3,2-d]pyrimidines in Anticancer Drug Discovery: Recent Advances in Drug Design and Molecular Targets2026
Design, synthesis, and biological evaluation of naphthalene imidazo[1,2‐<i>b</i>]pyridazine hybrid derivatives as VEGFR selective inhibitors2024
Pyrazolo[3,4- <i>d</i> ]pyrimidine derivatives as VEGFR-2 and EGFR <sup>T790M</sup> dual inhibitors: design, docking, ADMET, synthesis and anticancer evaluations2026
Organotin (IV)–4-(2-Thienyl) Butyric Acid Complexes Synergize with Vitamins D and E to Inhibit Breast Cancer Cell ProliferationMedicinal Chemistry · 2026
Evaluation of the Anticancer Potential of Nitro-Benzimidazole Derivatives in Breast CancerMedicinal Chemistry · 2026

MMore from Medicinal Chemistry

More from Cairo University

More from Al-Azhar University

More from Alfaisal University

More from Menoufia University

More from City of Scientific Research and Technological Applications

More from Princess Nourah bint Abdulrahman University

More from Almaarefa University