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May 26, 2024Brain Research BulletinOpen Access

Anti-glioma effect of paclitaxel mediated by specific mode electroacupuncture stimulation and the related role of the Hedgehog pathway

Congcong Ma Qinyu Ye Kecheng Qian Mengyuan Dai Lin Gan Jinding Yang Zhaoxing Jia Zixin Pan Qian Cai Tianxiang Jiang Xianming Lin

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Abstract

Paclitaxel (PTX) cannot effectively treat glioma because it cannot cross the bloodbrain barrier (BBB). A specific mode electroacupuncture stimulation (SMES) can temporarily open the BBB, thereby improving drug delivery to the brain. This study aimed to observe SMES-mediated accumulation of PTX in the brain and its anti-glioma effect and explore the role of the Hedgehog pathway.

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Ma et al. (2024) studied this question.

synapsesocial.com/papers/68e6859fb6db64358760e6fb https://doi.org/10.1016/j.brainresbull.2024.110985

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