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This is a Quantitative Study study (also classified as: Experimental Study).

October 8, 2025Scientific ReportsOpen Access

Design, synthesis, and antimicrobial evaluation of new triazole-tethered tetrazole hybrids via DNA gyrase inhibition

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Compounds 6a–6o exhibit significant antibacterial activity with MIC values between 1.56-3.12 µg/mL, outperforming ciprofloxacin.
High binding affinity of 6g and 6e to DNA gyrase was confirmed through molecular docking and dynamics analyses.
A multicomponent synthetic strategy was employed to create new triazole-tethered tetrazole derivatives, yielding favorable products.
This research suggests further exploration of these compounds against resistant microbial strains is warranted.

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Implication

Evaluation highlights new compounds' antibacterial activity against pathogenic microbial strains, suggesting potential in overcoming antimicrobial resistance.

Cite This Study

Agarwal et al. (2025) studied this question.

synapsesocial.com/papers/68e6860af44b9035634c2017 https://doi.org/10.1038/s41598-025-15919-4

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Implication

Evaluation highlights new compounds' antibacterial activity against pathogenic microbial strains, suggesting potential in overcoming antimicrobial resistance.

Design, synthesis, and antimicrobial evaluation of new triazole-tethered tetrazole hybrids via DNA gyrase inhibition

Key Points

Discussion

Implication

Cite This Study

Design, synthesis, and antimicrobial evaluation of new triazole-tethered tetrazole hybrids via DNA gyrase inhibition

Key Points

Discussion

Implication

Cite This Study

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