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October 7, 2025Frontiers in NutritionOpen Access

Structural characteristics of a neutral Glycyrrhiza uralensis polysaccharide and its fermentation properties on the gut microbiota of immunocompromised rats in vivo and vitro

Jie Sun Yixuan Wu Xinli Li Wenjie Xie Qingping Xiong Changxing Jiang Shu-Wan Tang Guoping Peng Yunfeng Zheng

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Key Points

GP-1 fermentation in immunocompromised rats enhances beneficial gut microbiota, promoting probiotic growth.
Analysis showed GP-1 has a molecular weight of 7.6 kDa and a unique glucan structure verified by spectroscopy techniques.
In vivo and in vitro results indicate GP-1 modulates gut microbiota balance and increases short-chain fatty acids production.
Structural characteristics reveal GP-1's potential as an effective prebiotic agent for gut health in immunocompromised individuals.

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Implication

Fermentation properties of polysaccharide GP-1 impact gut microbiota and short-chain fatty acids in rats, suggesting prebiotic potential.

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Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68e6860af44b9035634c2064 https://doi.org/10.3389/fnut.2025.1651015

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