SodaSulphanecobalamin as a Broad-Spectrum Medical Countermeasure Agent for Chemical and Biological Threats: Synthesis, Safety, and Comparative Analysis

Abstract Chemical and biological warfare agents (CBWAs) pose significant threats due to their acute toxicity and delayed treatment efficacy. This study evaluates SodaSulphanecobalamin (Na₄S₅CoC₆₉N₁₅H₈₉O₂₆), a novel medical countermeasure (MCM) agent, against diverse CBWAs, including cyanide, sulfur mustard, organophosphates, and dioxins. The antidote’s synthesis involves the thermal decomposition of sodium nitrite (NaNO₂) and sodium thiosulfate (Na₂S₂O₃) at 330–340°C, followed by reaction with hydroxocobalamin under platinum catalysis. The interaction of Nitric Oxide and hydroxocobalamin makes the active ingredient in this Medical Countermeasures Agent. Comparative rat models of acute cyanide toxicity demonstrated SodaSulphanecobalamin superior hemodynamic recovery (baseline mean arterial pressure restored within 5 minutes vs. 28–31 minutes for sodium nitrite-thiosulfate). The agent detoxifies cyanide via chelation, sulfur mustard via sulfur displacement, and organophosphates via phosphonic acid conversion. Unlike mercury-based antidotes for dioxins, SodaSulphanecobalamin eliminates chlorine atoms from 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), forming non-toxic sodium benzoate. With no adverse effects observed in animal trials, this MCM offers a safer, universal antidote platform.