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May 24, 2024Deleted JournalOpen Access

Efficiently targeting neuroblastoma with the combination of anti-ROR1 CAR NK cells and N-803 in vitro and in vivo in NB xenografts

Yaya Chu Gaurav Nayyar Meijuan Tian Dean A. Lee M. Fevzi Özkaynak Jessica Ayala-Cuesta Kayleigh Klose Keira Foley Alyssa S. Mendelowitz Wen Luo Yanling Liao Janet Ayello Gregory K. Behbehani Stanley R. Riddell Tim Cripe Mitchell S. Cairo

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Abstract

The prognosis for children with recurrent and/or refractory neuroblastoma (NB) is dismal. The receptor tyrosine kinase-like orphan receptor 1 (ROR1), which is highly expressed on the surface of NB cells, provides a potential target for novel immunotherapeutics. Anti-ROR1 chimeric antigen receptor engineered

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Chu et al. (2024) studied this question.

synapsesocial.com/papers/68e6885db6db643587610989 https://doi.org/10.1016/j.omton.2024.200820

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Abstract 3615: Targeting high-risk neuroblastoma by TGFβ imprinted natural killer cells2024
2Immunotherapy in Neuroblastoma: Mini-Review of Novel Directions and Challenges2025
3ROR2-specific CAR T cells are effective against hematologic and solid tumors and well tolerated in miceOriginal Research · 2025
4Next-generation CAR immunotherapy for neuroblastoma: expanding the role of immune cell platformsReview · 2026
5Data from Alpha-1 adrenergic antagonists sensitize neuroblastoma to therapeutic differentiation2024

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