Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model

Christopher C. Marvin; Adrian D. Hobson; Michael Mcpherson; Martin E. Hayes; Meena V. Patel; Diana L. Schmidt; Tongmei Li; John T. Randolph; Agnieszka K. Bischoff; Julia Fitzgibbons; Lu Wang; Lu Wang; Axel Hernandez; Ying Jia; Christian Goess; Shaughn H. Bryant; Suzanne Mathieu; Jianwen Xu

doi:10.1021/acs.jmedchem.4c00598

Abstract

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We describe the discovery of a thioester-containing glucocorticoid receptor modulator (GRM) payload and the corresponding antibody-drug conjugate (ADC). Payload

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Marvin et al. (2024) studied this question.

synapsesocial.com/papers/68e68be2b6db6435876134de https://doi.org/10.1021/acs.jmedchem.4c00598

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Abstract

This is the authors' abstract. We don't add key points for this paper.

We describe the discovery of a thioester-containing glucocorticoid receptor modulator (GRM) payload and the corresponding antibody-drug conjugate (ADC). Payload

Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model

Abstract

Discussion

Cite This Study

Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model

Abstract

Discussion

Cite This Study

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