Exercise-Drug Interaction in Blood Sugar Regulation: Insights from α-Glucosidase Inhibitors and Postprandial Exercise

Background: The global population is aging, and the diseases of these aging people are related to their living habits. Implementing a healthy diet, physical activity, and appropriate medication is equally important. This study explores the impact of 60% Maximum Heart Rate (MHR) exercise on blood sugar after taking α-glucosidase inhibitors-Nangapiry (α-GI-N) to explore optimal blood sugar control management. Methods: Seven healthy male college students participated in four experiments involving Group A (Control group), Group B (α-GI-N group, 2.5mg/kg), Group C (Exercise group, a 30-minute bicycle test at 60% MHR) and Group D (α-GI-N + Exercise group). The groups were compared using statistical tests to identify any differences. Results: According to the OSTT test, there were notable variations between groups B and D compared to the control group A after taking α-GI-N for 30 minutes. When exercise was added 30 minutes after consuming the α-GI-N, the exercise intensity of groups C and D was 63 ± 4% MHR, decreasing blood glucose to resting levels. Interestingly, the exercise test results showed no significant differences in heartbeat, oxygen uptake, and respiratory quotient collection between groups C and D. Additionally, α-GI-N did not affect exercise capacity or cause hypoglycaemia. Conclusion: A well-rounded lifestyle entails the proper medication, a nutritious diet, and consistent physical activity. An up-to-date study suggests that merging medication with exercise can effectively manage blood sugar levels. This approach presents a fresh avenue for regulating blood sugar and improving overall health by exercising after 30 minutes of eating.