Phase 1 open-label clinical trial reports the safety evaluation of BCMA-CD19 compound CAR T cells in systemic lupus erythematosus, highlighting targeted dual resetting of humoral immunity.
This study aims to evaluate the safety and efficacy of BCMA-CD19 compound chimeric antigen receptor T cells (cCAR) to dual reset the humoral and B cell immune system in patients with systemic lupus erythematosus (SLE) with lupus nephritis (LN).
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Wang et al. (2024) studied this question.
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