Assessment of the Effect of the Microbiome on the Development of Colorectal Cancer After Surgery on the Gastrointestinal Tract

We studied the influence of the microbiome on the development of colorectal cancer (CRC) after surgical interventions on the gastrointestinal tract (GIT) (appendectomy, cholecystectomy, polypectomy). 381 patients were analyzed; variables such as CRC mutational activity (KRAS, BRAF, MSI, NRAS, HER2) were included in the study. The analysis showed a high frequency of BRAF mutations in patients with a previous appendectomy, 4.8 times compared to the control group. We associate the obtained data with the influence of Fusobacterium nucleatum on the development of colorectal cancer, the role of which is described in modern literature. Cholecystectomy and polypectomy did not have a sufficient effect on the development of colorectal cancer.