Single-cell transcriptomic study characterizes peripheral leukocytes and T-cell receptor diversity in domestic cats, highlighting cellular pathways in feline immunodeficiency and cancer models.
The domestic cat (Felis catus) is a valued companion animal and a model for virally induced cancers and immunodeficiencies. However, species-specific limitations such as a scarcity of immune cell markers constrain our ability to resolve immune cell subsets at sufficient detail. The goal of this study was to characterize circulating feline T cells and other leukocytes based on their transcriptomic landscape and T-cell receptor repertoire using single cell RNA-sequencing.
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Ramarapu et al. (2024) studied this question.
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