Cerebrospinal fluid and plasma concentrations of the inflammatory marker sCD27 in a large surgical population

Highlights•CSF sCD27 correlates moderately with age and albumin quotient•Plasma sCD27 is related to BMI, smoking, hematological and neuropsychiatric disorders•Values were lower in a sub-cohort without systemic or neuropsychiatric disorders•sCD27 upper reference estimates are 416 pg/mL in CSF and 36,422 pg/mL in plasmaSummarySoluble CD27 (sCD27) is a potential biomarker for diseases involving immune dysfunction. As there is currently little data on cerebrospinal fluid (CSF) sCD27 concentrations in the general population we measured CSF and plasma concentrations in 486 patients (age range 18–92 years, 57% male) undergoing spinal anesthesia for elective surgery. Across the complete cohort the median [range] sCD27 concentrations were 163 [<50 to 7474] pg/mL in CSF and 4624 [1830 to >400,000] pg/mL in plasma. Plasma sCD27, age and Qalb were the factors most strongly associated with CSF sCD27 levels. Reference sCD27 concentration intervals (central 95% of values) in a sub-group without the indication of neuropsychiatric, inflammatory or systemic disease (158 patients) were <50 pg/mL – 419 pg/mL for CSF and 2344–36422 pg/mL for plasma. These data provide preliminary reference ranges that could inform future studies of the validity of sCD27 as a biomarker for neuro- and systemic inflammatory disorders.