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May 21, 2024Open Access

Acarbose Impairs Gut Bacteroides Growth by Targeting Intracellular GH97 Enzymes

Haley A. Brown Adeline L. Morris Nicholas A. Pudlo A. Hopkins Eric C. Martens Jonathan L. Golob Nicole M. Koropatkin

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Abstract

Acarbose is a type-2 diabetes medicine that inhibits dietary starch breakdown into glucose by inhibiting host amylase and glucosidase enzymes. Numerous gut species in the

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Brown et al. (2024) studied this question.

synapsesocial.com/papers/68e69359b6db643587619ab0 https://doi.org/10.1101/2024.05.20.595031

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Acarbose differentially affects gut microbial metabolism of maltose and sucrose, distinctly modulating host metabolismOriginal Research · 2026
2Effects of Acarbose, an α-Glucosidase Inhibitor (BAY G 5421), on Orally Loaded Glucose, Maltose and Sucrose and on Blood Glucose Control in Non-Insulin-Dependent DiabeticsOriginal Research · 1985
3Two weeks of acarbose treatment show no effect on gut microbiome composition in patients with type 2 diabetes: a randomised, placebo-controlled, double-blind, crossover study2024 · 3 citations
4Acarbose glycosylation by AcbE for the production of acarstatins with enhanced α-amylase inhibitory activity2024 · 6 citations
5Acarbose redirects gut microbiome utilization of dietary carbohydrates to suppress anaphylaxis in miceOriginal Research · 2026 · 1 citations

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