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May 20, 2024PeerJOpen Access

PTX3 mediates PI3K/AKT/mTOR signaling to downregulate apoptosis and autophagy to attenuate myocardial injury in sepsis

Na Cui Zhi Chen Zhanbiao Yu Xiaowei Lv Zhenjie Hu

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Abstract

This study aimed to investigate the effect and mechanism of Pentraxin 3 (PTX3) on myocardial injury in sepsis.

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Cite This Study

Cui et al. (2024) studied this question.

synapsesocial.com/papers/68e694b6b6db64358761af8f https://doi.org/10.7717/peerj.17263

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Cardioprotective Function of the Long Pentraxin PTX3 in Acute Myocardial Infarctionpreclinical · 2008 · 326 citations
2Pentraxin 3 promotes the expression of pro-inflammatory cytokines and the migration of macrophages in myocarditispreclinical · 2025 · 3 citations
3Targeting of Pentraxin 3 Alleviated Cardiac Hypertrophy in Mice Induced by Angiotensin <scp>II</scp>preclinical · 2026
4Prognostic Significance of the Long Pentraxin PTX3 in Acute Myocardial Infarctioncohort · 2004 · 431 citations
5PTX3, A Prototypical Long Pentraxin, Is an Early Indicator of Acute Myocardial Infarction in Humanscohort · 2000 · 428 citations

Long Pentraxin PTX3 Exacerbates Pressure Overload–Induced Left Ventricular Dysfunction2013
Pentraxin 3 Activates JNK Signaling and Regulates the Epithelial-To-Mesenchymal Transition in Renal Fibrosis2016
Elevated Plasma Level of Pentraxin-3 Predicts In-Hospital and 30-Day Clinical Outcomes in Patients with Non-ST-Segment Elevation Myocardial Infarction Who Have Undergone Percutaneous Coronary Intervention2014
Association between antibiotic exposure and survival outcomes in hepatocellular carcinoma patients treated with immune checkpoint inhibitors: a systematic review and meta-analysisPeerJ · 2026
The effects of a structured badminton program on social and emotional learning in adolescentsPeerJ · 2026

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