Heterologous prime-boost vaccination drives early maturation of HIV broadly neutralizing antibody precursors in humanized mice

Christopher A. Cottrell; Xiaozhen Hu; Jeong Hyun Lee; Patrick Skog; Sai Luo; Claudia T. Flynn; Katherine McKenney; Jonathan Hurtado; Oleksandr Kalyuzhniy; Alessia Liguori; Jordan R. Willis; Elise Landais; Sebastian Raemisch; Xuejun Chen; Sabyasachi Baboo; Sunny Himansu; Jolene K. Diedrich; Hongying Duan; Cheng Cheng; Torben Schiffner; Daniel Bader; Daniel W. Kulp; Ryan Tingle; Erik Georgeson; Saman Eskandarzadeh; Nushin Alavi; Danny Lu; Troy Sincomb; Michael Kubitz; Tina-Marie Mullen; John R. Yates; James C. Paulson; John R. Mascola; Frederick W. Alt; Bryan Briney; Devin Sok; William R. Schief

doi:10.1126/scitranslmed.adn0223

Abstract

A protective HIV vaccine will likely need to induce broadly neutralizing antibodies (bnAbs). Vaccination with the germline-targeting immunogen eOD-GT8 60mer adjuvanted with AS01

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Cottrell et al. (2024) studied this question.

synapsesocial.com/papers/68e69af9b6db643587620b2a https://doi.org/10.1126/scitranslmed.adn0223

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Heterologous prime-boost vaccination drives early maturation of HIV broadly neutralizing antibody precursors in humanized mice

Abstract

Discussion

Cite This Study

Heterologous prime-boost vaccination drives early maturation of HIV broadly neutralizing antibody precursors in humanized mice

Abstract

Discussion

Cite This Study

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