Natural experiment reveals neurobehavioral diagnoses following childhood operative anesthesia, indicating risks independent of preexisting conditions.
Observational studies of anesthetic neurotoxicity may be biased because children requiring anesthesia commonly have medical conditions associated with neurobehavioral problems. This study takes advantage of a natural experiment associated with appendicitis to determine whether anesthesia and surgery in childhood were specifically associated with subsequent neurobehavioral outcomes.
No takes yet. Share an insight, caveat, or question.
Silber et al. (2024) studied this question.