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May 16, 2024iScienceOpen Access

Expression of GAD2 in excitatory neurons projecting from the ventrolateral periaqueductal gray to the locus coeruleus

Erika K. Harding Zizhen Zhang Júlia Canet-Pons Sierra Stokes-Heck Tuan Trang Gerald W. Zamponi

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Abstract

The ventrolateral periaqueductal gray (vlPAG) functionally projects to diverse brain regions, including the locus coeruleus (LC). Excitatory projections from the vlPAG to the LC are well described, while few studies have indicated the possibility of inhibitory projections. Here, we quantified the relative proportion of excitatory and inhibitory vlPAG-LC projections in male and female mice, and found an unexpected overlapping population of neurons expressing both GAD2 and VGLUT2. Combined

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Cite This Study

Harding et al. (2024) studied this question.

synapsesocial.com/papers/68e69b09b6db643587621202 https://doi.org/10.1016/j.isci.2024.109972

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