"Exploring Cardiac Vector Propagation in Acute Myocardial Infarction: A Spatial Velocity Perspective"

Aims To objectively characterize the spatial-velocity dynamics of the QRS-loop in the vectorcardiogram (VCG) of patients with acute myocardial infarction (AMI). Methods VCG was constructed as space curve from three orthogonal ECG leads of 25 healthy individuals and 50 AMI patients. Spatial-velocity (SV) of the dynamic QRS loop was recorded, along with component attributes such as changing spatial distance (SD) and magnitude. Results Decreased SV and SD and altered spatial propagation patterns of ventricular vectors in AMI was recorded, with changes in specific axes based on infarct location. Reduced left-ventricular ejection-fraction indicates systolic dysfunction in AMI. Conclusion Altered spatial propagation patterns of vectors and ventricular dysfunction may be explained by complex interplay between mechanical and electrical factors in AMI. Declaration The present manuscript has been submitted in the journal Future Cardiology , and currently under peer review None of the manuscript’s contents have yet been published. All authors have read and approved the manuscript and approved its submission to MedRxiv, as preprint server. They also agreed the order of authorship.