Laboratory study demonstrates striatin knockout induces sodium current gain and impaired calcium handling in mouse stem cell-derived cardiomyocytes, highlighting pathogenicity mechanisms.
Striatin (Strn) is a scaffold protein expressed in cardiomyocytes (CMs) and alteration of its expression are described in various cardiac diseases. However, the alteration underlying its pathogenicity have been poorly investigated.
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Benzoni et al. (2024) studied this question.
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