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May 15, 2024Journal of NeurochemistryOpen Access

Artificial fluorescent sensor reveals pre‐synaptic NMDA receptors switch cholecystokinin release and LTP in the hippocampus

Yin‐Ting Wong Xuejiao Zheng Siu‐Hin Lau Ka‐Hei Murphy Sun Xi Chen Huangcan Li Siu‐Lung Ng Hehai Jiang Geoffrey Chun Yue Lau Jufang He

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Abstract

Cholecystokinin (CCK) has been confirmed to be essential in NMDA-dependent long-term potentiation (LTP) at mouse cortical synapses. This paper has proven that CCK is necessary for LTP induced by high-frequency stimulation of mouse hippocampal synapses projected from the entorhinal cortex. We show that the subunit of the axonal NMDA receptor dominant modulates the activity-induced LTP by triggering pre-synaptic CCK release. A functional pre-synaptic NMDA receptor is required to induce LTP mediated by the axonal Ca

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Cite This Study

Wong et al. (2024) studied this question.

synapsesocial.com/papers/68e69fffb6db643587623aef https://doi.org/10.1111/jnc.16128

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