The total synthesis of marine macrolide glycoside (−)-irijimaside A is described. Key to the synthesis is the convergent fragment assembly enabled by nickel/zirconocene-mediated one-pot reductive ketone coupling. At the last stage of the synthesis, Stille coupling and glycosylation led to the first total synthesis of (−)-irijimaside A.
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Suwa et al. (2024) studied this question.
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