Meta-analysis of randomized controlled trials comparing cyanoacrylate glue to standard methods for securing IVCs, suggesting potential benefits in some patient populations.
Background: Intravenous catheters (IVCs) are a common medical device, used in 70% of hospital patients. Due to their high failure ratio (35%–50%) and complications, we aimed to perform a systematic review and meta-analysis to assess the efficacy of Cyanoacrylate Glue (CG) use in preventing IV complications at the Emergency Department. Methods: This study was registered in PROSPERO on February 5, 2025, with registry number CRD42025642588 and received no financial support. A systematic search at PubMed, Embase, and Cochrane databases was performed and only Randomized Controlled Trials about CG use for securing IVCs were included. Results: Primary outcomes showed no statistical significance between the groups across all four outcomes at maximum follow-up. However, in a subgroup analysis including only adult patients, CG group presented lower IVCs dislodgement and failure events. Further studies in pediatric patients are needed.
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