IL-4 Licenses B Cell Activation Through Cholesterol Synthesis

Holly R. Steach; Autumn G. York; Mathias H. Skadow; Shuting Chen; Jun Zhao; Kevin J. Williams; Quan Zhou; Weu-Yuan Hsieh; J. Richard Brewer; Rihao Qu; Justin A. Shyer; Christian C. D. Harman; Esen Sefik; Walter K. Mowell; Will Bailis; Can Cui; Yuval Kluger; Steven J. Bensinger; Joe Craft; Richard A. Flavell

doi:10.1101/2024.05.13.593964

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Abstract

Lymphocyte activation involves a transition from quiescence and associated catabolic metabolism to a metabolic state with noted similarities to cancer cells such as heavy reliance on aerobic glycolysis for energy demands and increased nutrient requirements for biomass accumulation and cell division

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Steach et al. (2024) studied this question.

synapsesocial.com/papers/68e6a14db6db6435876252a5 https://doi.org/10.1101/2024.05.13.593964

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IL-4 Licenses B Cell Activation Through Cholesterol Synthesis

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IL-4 Licenses B Cell Activation Through Cholesterol Synthesis

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